RECONSTRUCTION & DOSIMETRY METHODS
Quantitative Reconstruction & Dosimetry: Software Platform Modules
The methods and workflows below are compiled from the official Hermes Medical Solutions instructions for use, product pages and white papers, and correspond to HERMIA reconstruction and dosimetry modules. Module names, algorithms, isotope support and configuration follow the manufacturer documentation.
METHOD · HYBRID
Hybrid Dosimetry (organ dose workflow)
Serial WB / SPECT-CT registration → ROI / VOI → count-to-activity conversion → TAC fitting and integration → OLINDA/EXM (MIRD) dose. Corresponds to the HERMIA Organ Dosimetry workflow.
TAC · TIAC · MIRD · OLINDA
METHOD · VOXEL
Voxel Dosimetry
Monte Carlo photon transport through the patient CT yields voxel dose maps, DVHs and dose tables, with deformable registration and semi-automatic segmentation. Hermes lists ²²⁵Ac, ²¹¹At, ²¹²Pb, ¹⁷⁷Lu, ⁹⁰Y and ⁸⁹Zr among supported isotopes.
DOSE MAP · DVH · MC TRANSPORT
METHOD · MONTE CARLO
Monte Carlo dose calculation
Monte Carlo is used twice: photon transport for voxel dose, and collimator–detector response modelling in SPECT reconstruction (high-energy isotopes such as ¹²³I, ¹³¹I, ⁹⁰Y; specific isotope–collimator combinations only).
PHOTON TRANSPORT · COLLIMATOR RESPONSE
METHOD · SPECT
Quantitative SPECT Reconstruction
Iterative reconstruction compensates attenuation, collimator blur, scatter and noise; CT attenuation maps, scatter windows and SUV-SPECT® calibration convert counts to activity / SUV.
SUV-SPECT® · ATTENUATION · SCATTER
METHOD · ALPHA
²²⁵Ac and alpha-emitter reconstruction
HERMIA Voxel Dosimetry lists ²²⁵Ac, ²¹¹At and ²¹²Pb. Energy windows, collimators, calibration and reconstruction parameters for alpha emitters require verification per camera and protocol.
²²⁵Ac · ²¹¹At · ²¹²Pb
CHAIN · FROM IMAGE TO DOSE
From image to absorbed dose
- Quantitative SPECT / PET reconstruction and activity calibration
- Time–activity curve fitting, cumulated activity / residence time
- Organ dose (MIRD / OLINDA) or voxel dose (Monte Carlo)
- Dose map, DVH and dose results table
As software platform modules
HERMIA provides quantitative SPECT reconstruction, Hybrid / Voxel Dosimetry, OLINDA/EXM and SIRT planning modules. Module names, algorithms, isotope support and configuration follow the Hermes documentation.