Acquisition & reconstruction protocol design
Develop, review and harmonise acquisition and reconstruction parameters across sites.
QUANTITATIVE IMAGING COMPUTING · SHANGHAI, CHINA
NDMed (NuSight Digital Medical) provides quantitative molecular imaging computation and dosimetry calculation services for radiopharmaceutical IIT and Phase I–III clinical trials, covering quantitative metrics in neuro, cardiac and oncological imaging, multi-site imaging QC and result delivery. Scope is defined per project.
Quantitative imaging · Radiopharmaceutical dosimetry · Multi-site imaging QC · Neuro / Cardiac / Oncology
Quantitative imaging computationQUANTITATIVE IMAGING
Internal radiation dosimetryINTERNAL DOSIMETRY
Multi-site harmonisationMULTI-SITE HARMONISATION
GCP documentation & traceabilityDOCUMENTATION & TRACEABILITY
SERVICE OVERVIEW
For radiopharmaceutical IIT and Phase I–III clinical trials. Quantitative scoring (CenTauR, PSMA) and radiopharmaceutical dosimetry calculation belong to this computing service; acquisition parameters, quantitative metrics and result delivery are defined per project.
SERVICE STAGES
Acquisition and reconstruction parameters are documented and harmonised across sites; image data handover, quantitative metric definitions and delivery formats are defined per project; QC records are retained for traceability.
COMPUTING SERVICES · CLINICAL TRIALS
Quantitative imaging and internal dose calculation per project protocol, covering protocol harmonisation, phantom-based site qualification, per-timepoint image QC and result delivery. Metrics, implementation and validation are defined per project.
Develop, review and harmonise acquisition and reconstruction parameters across sites.
EARL / NEMA phantom studies (uniform, NEMA and Hoffman phantoms) to qualify site equipment.
Tumour / organ / lesion quantification, TAC modelling and PBPK analysis, quantitative neuroimaging scoring.
Organ dose, tumour dose, whole-body retention and effective dose from quantitative PET / SPECT.
Pre-treatment ⁹⁹ᵐTc-MAA SPECT planning (lung shunt, tumour and normal-liver dose); post-treatment ⁹⁰Y PET verification and voxel dose maps.
Quantitative scoring delivered as computing services: CenTauR (tau PET), PSMA PET lesion uptake and enrolment assessment, and result calculation for standardised scales. Metrics, implementation and validation are defined per project.
QUANTITATIVE SCORING · COMPUTING SERVICES
CenTauRTau PET · cross-tracer standardised scale
PSMAPSMA PET · lesion uptake quantification and enrolment assessment
SERVICE FIGURES
Original schematic figures illustrating the workflow and methodology of our computing services. These are not real subject images, measured data or project deliverables.
SCHEMATIC · NOT PATIENT DATA
Multi-site imaging QC and protocol harmonisation
Acquisition and reconstruction parameters are documented and harmonised across sites; phantom validation, per-timepoint image QC and centralised quantitative computation are defined per project.
From time–activity curves to dose results
Serial quantitative images yield fitted time–activity curves and integrated time-integrated activity, then organ or voxel doses. Fitting methods and validation are defined per project.
ROI / VOI and quantitative metric definitions
Lesion, organ and regional uptake quantification depends on contour definition, activity calibration and metric conventions. Metric definitions, implementation and validation are defined per project.
Figures are original NDMed methodology schematics, not real subject images, measured curves or deliverables. Metrics, parameters, validation and deliverables are defined per project.
CLINICAL AREAS
One quantitative computation and QC workflow; imaging metrics, timepoints and deliverables are defined per clinical area and per project.
NEURO · MOLECULAR IMAGING
Regional brain PET quantification, longitudinal consistency checks and result calculation for standardised scales (e.g. CenTauR). Metric definitions, implementation and validation are defined per project.
CARDIAC · IMAGING
Uptake quantification and multi-timepoint consistency checks for cardiac SPECT / PET. Quantitative metrics and thresholds are defined per project.
ONCOLOGY · THERANOSTICS
Tumour / organ / lesion uptake quantification, PSMA PET enrolment assessment support, time–activity curve fitting and internal radiation dosimetry.
COMPUTING-SERVICE METHODOLOGY
RECONSTRUCTION & DOSIMETRY METHODS
The reconstruction and dosimetry methods NDMed applies in clinical-trial quantitative computation. Parameter choices, implementation and validation are defined per project; each isotope–camera combination is confirmed per project.
METHOD · HYBRID
Serial whole-body / SPECT-CT registration → ROI / VOI → count-to-activity conversion → time–activity curve fitting and integration → MIRD organ dose calculation.
TAC · TIAC · MIRD
METHOD · VOXEL
Monte Carlo photon transport through the patient CT yields voxel dose maps, DVHs and dose tables, with deformable registration and semi-automatic segmentation. Scope is defined per project.
DOSE MAP · DVH · MC TRANSPORT
METHOD · MONTE CARLO
Used twice: photon transport for voxel dose, and collimator–detector response modelling in SPECT reconstruction (high-energy isotopes; specific isotope–collimator combinations only).
PHOTON TRANSPORT · COLLIMATOR RESPONSE
METHOD · SPECT
Iterative reconstruction compensates attenuation, collimator blur, scatter and noise; CT attenuation maps, scatter windows and activity / SUV calibration convert counts to quantitative values.
ATTENUATION · SCATTER · CALIBRATION
METHOD · ALPHA
Energy windows, collimators, calibration and reconstruction parameters for ²²⁵Ac, ²¹¹At and ²¹²Pb require verification per camera and protocol.
²²⁵Ac · ²¹¹At · ²¹²Pb
CHAIN · FROM IMAGE TO DOSE
As computing-service methodology
NDMed applies these methods per protocol for quantitative reconstruction, time–activity curve fitting and internal dose calculation. Parameter choices, implementation, validation and delivery formats are defined per project, with QC records and documentation retained.
METHODOLOGICAL APPLICATIONS
Methodological scenarios beyond standard dosimetry; whether they are applied is defined per project.
Lu-177 therapy dose data→Cross-isotope dose modelling→Ac-225 / Pb-212 alpha dose prediction
Using Lu-177 data to support dose exploration and protocol design in alpha-emitter RLT.
Low-dose Lu-177 imaging→Pharmacokinetic extrapolation→FIH therapeutic dose prediction
Supporting dose escalation for new RLT agents with lower radiation exposure.
PSMA PET images→Quantitative lesion uptake assessment→Subject enrolment decision support
Replacing subjective reading with objective numbers for consistent, traceable enrolment.
Single-time-point SPECT / PET→Time–activity curve extrapolation→Organ / lesion dose estimation
Reducing a multi-visit dosimetry workflow to a single imaging session.
This methodology description is drawn from published literature on MIRD organ dosimetry, Monte Carlo particle transport and quantitative SPECT reconstruction; implementation, parameters, validation and deliverables are defined per project, with QC records and documentation retained.
SCOPE
Diagnostic imaging, beta-minus therapy and alpha therapy isotopes. Confirm the scope for each project.
DIAGNOSTIC IMAGING
⁶⁸Ga
¹⁸F
⁸⁹Zr
⁶⁴Cu
BETA / AUGER THERAPY
¹⁷⁷Lu
⁹⁰Y
¹⁶¹Tb
ALPHA THERAPY
²²⁵Ac
²¹¹At
²¹²Pb
Small molecules
Peptides
Nanobodies
Oncology
Neuro molecular imaging
Cardiac imaging
IIT
Phase I–III
Isotopes and indications are compiled from company materials and the NDMed WeChat official account; confirm the scope for each project.
QUALITY MANAGEMENT
Good Clinical Practice (GCP) for pharmaceutical clinical trials
WHO WE WORK WITH
Pharma / sponsorsR&D and clinical development teams
CROsClinical operations and imaging management
Hospitals / nuclear medicineClinical research sites
Research institutionsMedical imaging research
ABOUT US
NDMed provides quantitative molecular imaging computation and dosimetry calculation services for radiopharmaceutical clinical trials, covering quantitative imaging QC, pharmacokinetic modelling, individualised radiation dose assessment and result delivery. Based in Shanghai, China.
Chinese legal name上海睿观数科医药科技有限公司
English legal nameShanghai NuSight Digital Medical Technology Ltd.
Brand / short nameNDMed · 睿观数科 · NuSight Digital Medical
To discuss a clinical-trial computing service plan, imaging metric definitions or deliverables, please contact us through our WeChat official account.
OFFICIAL WECHAT ACCOUNT
WeChat Official Account: 睿观数科 (NDMed)
Use the Business Cooperation menu item or leave a message. Further technical content is available on the account.